Rosiglitazone and Metformin have opposite effects on intestinal absorption of oligopeptides via the Proton-dependant PepT1 transporter
نویسندگان
چکیده
Clinical Pharmacy Department (EA4123), Faculty of Pharmacy, Paris-Sud 11 University, Châtenay-Malabry, France (P.H., C.B., L.B., R.F., M.B.). Pharmacy Department, Pitié-Salpétrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France (P.H., M.B.). Inserm U773, Paris Diderot University, Sorbonne Paris Cité, UMRS 773, Paris, France (A.B.). Molecular Pharmacology Fast Forward. Published on November 22, 2011 as doi:10.1124/mol.111.073874
منابع مشابه
Rosiglitazone and metformin have opposite effects on intestinal absorption of oligopeptides via the proton-dependent PepT1 transporter.
The intestinal H(+)/peptide cotransporter 1 (PepT1) plays a major role in nitrogen supply to the body by mediating intestinal absorption of di- and tripeptides. Previous studies have reported that in animal models of type 2 diabetes/obesity, PepT1 activity and expression were markedly reduced. This prompted us to investigate the effects of two antidiabetic drugs, rosiglitazone and metformin, on...
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The primary objective of this study was to determine the in vivo absorption properties of valacyclovir, including the potential for saturable proton-coupled oligopeptide transporter 1 (PepT1)-mediated intestinal uptake, after escalating oral doses of prodrug within the clinical dose range. A secondary aim was to characterize the role of PepT1 on the tissue distribution of its active metabolite,...
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